The 23-year-old has joined in time for the Absa Premiership visit to Orlando Pirates on Saturday.
Manyama is a good footballer, a top-class player," SuperSport boss Cavin Johnson said. "I think he will be a fantastic addition to the squad."
He added: "We have got a lot of fixtures coming up and so we are going to need a good squad of quality players for that, and we hope Lebo will blend it nicely with the rest of the players we have."
Manyama began his professional career with Ajax Cape Town where he spent three fruitful years that saw him get a call-up into the national team. The winger netted 15 goals in 71 starts for the Urban Warriors since his arrival in Cape Town.
The Alex-born player has attributed his decision to joining Matsatsantsa to the brand of football the team is associated with and the man steering the ship, Cavin Johnson.
“The coach was a very big factor for me. He showed me from the beginning that he really wanted me,” says Manyama.